Ketamine is an anaesthetic and also a pain-management drug, it’s mainly used as a horse tranquilizer and is not approved by the FDA. It can have hallucinogenic effects and invoke feelings of detachment – a floaty, out-of-body type experience. Ketamine’s a class B drug, so recreational use can get you into considerable trouble with the law…However it has been trialled as a short-term treatment for severe depression and there seem to be some positive outcomes. It seems that the effects are not long-lasting but can alleviate some of the worst symptoms of depression with relative speed. Essentially it helps you begin to get your mojo back.
I like the sound of that.
It’s probably not going to arrive at a pharmacy near you any time soon, but it’s one to keep an eye on. In the meantime you’ll have to make do with trippy kids programmes and camomile tea.
So this is one of my new enterprises. Just thought I’d leave this here in case anyone’s having a greetings card emergency situation. Y’know. In case.
You can click for a look if you like.
That’s all for the shameless self – promotion 🙂 x
Well I’ve been tiptoeing around the web trying to find out what’s going on in the world of Mood Research and it’s made my brain ache a bit. So many diagrams, so many long words. Anyway, I’ve picked out a few choice things (that I vaguely understood) to share with you.
It has been suggested that the manic-depressive episodes of bipolar disorder are the result of a kind of evolutionary ‘feedback loop’ gone awry eg. our successes generate confidence and failures a lack thereof. This feedback loop misfires in bipolar disorder and creates an exaggerated perception of success/failure leading to an unbalanced sense of confidence (‘of course I can build a flying machine, just one more empty washing up liquid bottle and we’re airborne!’) or inadequacy (‘ I failed to create a flying machine because I am a worthless mess of a human & will never know love’) But, this doesn’t really explain why the feedback is all wonky in the first place, which is kind of what I want to know.
Research points to a genetic factor, according to The Black Dog Institute, having a parent with BAD gives you a 10% chance of developing the disorder, rising to 40% if both of your parents have it. It kind of goes without saying that stressful life events play a role in triggering symptoms of the disorder, but you can’t blame them for ‘causing’ it…and you’d need to have a word with your pineal gland and a whole raft of neurotransmitters to find out what on earth they are doing to make your moods bounce around so much. Nobody’s worked out how to communicate with the little critters as yet.
Brain imaging though, seems to be making progress into picking out the general areas of the brain that are doing odd things in patients with bipolar disorder. According to Psycheducation
Evidence is growing quite strong that a region of the brain called the medial prefrontal cortex is underactive in people with bipolar disorder even when they are having no symptoms at all.
My basic understanding is that this underactive cortex wotsit is linked to decision-making and multi-tasking eg. difficulties with. Makes sense. And…this part of the brain has been shown to be more active in those taking mood medications. Which implies correlation at least.
I’m still pretty sure my brain looks like this
but I can’t prove anything. Yet.
Anyway, my next little wander round the net is going to involve Ketamine. Reading about, not taking (the internet doesn’t need Ketamine. It’s weird enough. As am I) Apparently it’s being trialled as a treatment…interesting…
Busy times afoot in the Breaking B.A.D house, my exploration into ways to work from home led me to set up a website for my own enterprise (long running but a bit neglected) and also to start putting my doodling to good use by designing some greetings cards (cheeky plug) and setting up the means of attempting to sell them. I’m also job-hunting…I have plenty of enthusiasm for entrepreneurial ventures but I don’t think they’ll cover the rent so I’m going to need a day job. Luckily I’m probably in a decent position to get agency work, but I’m wary of getting drawn back in to the same career. If anyone needs a slightly odd but friendly bookseller, look no further! I can start Monday 🙂
Anyway, having been side tracked by recent events I am back on the mission to find ways to break B.A.D and this month’s slightly late starter is going to involve checking out the science bit and finding out about more on research, theories, therapies, meds and all that jazz – know thine enemy. Here’s what NIMH has to say about the current status of neuroimaging and mental illness.
It’s nice to be back, I shall try to stay well enough not to whinge for a while.